Dissolution test of various low-dose acetylsalicylic acid preparations marketed in Indonesia
نویسندگان
چکیده
Metode Studi disolusi dilakukan mengikuti Farmakope Amerika (USP)/Eropa, metode A, menggunakan alat 1 USP (keranjang) 100 rpm, dengan 2 media: 0,1 N HCl, 120 menit untuk stadium asam, dan buffer fosfat pH 6,8, 90 menit untuk stadium dapar. Sampel diambil pada 120 menit untuk stadium asam, dan setiap 10 menit sampai dengan 90 menit untuk stadium dapar. Asam asetilsalisilat diukur kadarnya dengan spektrofotometer pada 280 nm untuk stadium asam, dan pada 265 nm untuk stadium dapar. Asam salisilat bebas diukur kadarnya hanya pada akhir stadium dapar dengan metode HPLC. Ada 6 produk uji (Cardio Aspirin® 100 mg, Aptor® 100 mg, Ascardia® 80 mg, Thrombo Aspilet® 80 mg, Astika® 100 mg dan Farmasal® 100 mg), 3 batch untuk setiap produk, dan 6 unit untuk setiap batch.
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The use of Acetyl Salicylic Acid (ASA) in the secondary prevention of cardio vascular diseases is well known. Orally administered ASA is rapidly metabolized to its principal metabolite Salicylic Acid (SA) in the gastrointestinal fluids, during absorption in the intestine and liver. ASA, and not its hydrolysis product SA, which exhibits antithrombotic activity. Transdermal delivery of acetylsali...
متن کاملTransdermal Delivery Offer for Low-Dose Acetylsalicylic Acid. J Pharm Res 2016, 1(1): 000103
The use of Acetyl Salicylic Acid (ASA) in the secondary prevention of cardio vascular diseases is well known. Orally administered ASA is rapidly metabolized to its principal metabolite Salicylic Acid (SA) in the gastrointestinal fluids, during absorption in the intestine and liver. ASA, and not its hydrolysis product SA, which exhibits antithrombotic activity. Transdermal delivery of acetylsali...
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